Oscar-winnerRenee Zellwegerwill introduce the performance.
The series ran on NBC for two seasons, ending its run in 2013.
The special event streams Wednesday at 8 p.m.
Mark Seliger/NBC
ET and will benefit The Actors Fund, striving to help artists in need during the coronavirus crisis.
Were grateful to everyone at The Actors Fund and PEOPLE for their love of the performing arts.
Watch the reunion and concert in the video above.
